Francois du Plessis again showed his class as Lancashire cruised to a fourth Twenty20 Cup victory to stay top of the North Division at Grace Road.
Chasing Leicestershire's 147-3, the visitors were wobbling on 47-3 when Steven Croft was run out.
But du Plessis surpassed his previous Twenty20 best with the last of his 13 fours as he hit an unbeaten 78 off 49 balls to help get his side home.
Earlier, James Allenby had batted through for the Foxes, making 71.
Lancashire now test their 100% against Derbyshire at Old Trafford on Tuesday night (2 June, 1730 BST).